Aging is characterized by the decline and deterioration of functional cells and results in a wide variety of molecular damages and reduced physical and mental capacity. The knowledge on aging process is important because life expectancy is expected to rise until 2050. Aging cannot be considered a homogeneous process and includes different trajectories characterized by states of fitness, frailty, and disability. Frailty is a dynamic condition put between a normal functional state and disability, with reduced capacity to cope with stressors. (...) This geriatric syndrome affects physical, neuropsychological, and social domains and is driven by emotional and spiritual components. Sarcopenia is considered one of the determinants and the biological substrates of physical frailty. Physical and cognitive frailty are separately approached during daily clinical practice. The concept of motoric cognitive syndrome has partially changed this scenario, opening interesting windows toward future approaches. Thus, the purpose of this manuscript is to provide an excursus on current clinical practice, enforced by aneddoctical cases. The analysis of the current state of the art seems to support the urgent need of comprehensive organizational model incorporating physical and cognitive spheres in the same umbrella. (shrink)

This article compares the phenomena of “tic” and “slip of the tongue” [lapsus] as they have been described by Maine de Biran and Victor Egger, including a possible reception of Biran’s thought by Egger. In the twentieth century these phenomena will be analysed by psychoanalysts, but their first description appears in nineteenth-century French philosophy. Emerging from the analysis of Biran’s “tics” and Egger’s “slips” in the nineteenth century, the concept of habit becomes linked to a reflection on the unconscious. Tic (...) and slip of the tongue constitute, each in its own way, the place where habit exhibits its most peculiar characteristic, that of being always suspended in the dual dialectic of the voluntary and the involuntary, of the conscious and the unconscious. Maine de Biran’s “habit tics” underline the tendency set by habit for which voluntary and conscious actions become involuntary and unconscious, whereas Egger defines slip of the tongue as an involuntary and unconscious event that allows the birth of new habits. (shrink)

The volume provides the first book-length study of Chrysostomus Javelli’s philosophical works. An Italian university professor and a prominent figure in the intellectual landscape of sixteenth-century Europe, Javelli (ca. 1470-1540) was the author of insightful commentaries on both Plato and Aristotle as well as of original works in which he laid the foundations of a new Christian philosophy. In this volume, a group of leading scholars from around the world guide readers through the many facets of Javelli’s philosophical corpus, showing (...) the long-term impact of his ideas on Western philosophical thought. The twelve essays of this volume shed light on an understudied yet central figure of Renaissance culture, revealing new connections and unexplored influences. This book is a valuable tool for students and scholars of early modern philosophy, classical tradition, and Christian theology, contributing to the understanding of a neglected chapter of Western intellectual history. (shrink)

The first study, along with edition and translation, of Chrysostomus Javelli’s epitome of the _Liber de bona fortuna_ (1531), a work permitting insight into the early modern understanding of fortune, fate, and free will.

v. 1. L'educazione come legge della persona.

Fertilization triggers cytoplasmic movements in the frog egg that lead in mysterious ways to the stabilization of β‐catenin on the dorsal side of the embryo. The novel Huluwa (Hwa) transmembrane protein, identified in China, is translated specifically in the dorsal side, acting as an egg cytoplasmic determinant essential for β‐catenin stabilization. The Wnt signaling pathway requires macropinocytosis and the sequestration inside multivesicular bodies (MVBs, the precursors of endolysosomes) of Axin1 and Glycogen Synthase Kinase 3 (GSK3) that normally destroy β‐catenin. In (...) Xenopus, the Wnt‐like activity of GSK3 inhibitors and of Hwa mRNA can be blocked by brief treatment with inhibitors of membrane trafficking or lysosomes at the 32‐cell stage. In dorsal blastomeres, lysosomal cathepsin is activated and intriguing MVBs surrounded by electron dense vesicles are formed at the 64‐cell stage. We conclude that membrane trafficking and lysosomal activity are critically important for the earliest asymmetries in vertebrate embryonic development. (shrink)

I deal with the issue of the environmental crisis from the perspective of a phenomenologically embedded qualitative social ontology. The first point I make is that our environment is a «personal world», and not a «naturalistic world»: a world that is experienced in the «personalistic attitude» and as such is an ontologically qualitative world, in which both natural and social entities are given to us as essentially constituted by value-qualities and meanings, and not as merely material things. The second point (...) I argue for is that our environment is also a «common-surrounding world» whose personal collectives are its essential correlate: «common-surrounding world» and personal collectives existentially depend on one another, and human persons, both individual and collective, are responsible for the existence of their environment and its entities. I apply the tools of phenomenological eidetics to the ideas of «personal world» and «common-surrounding world», and inquire into the ontologically qualitative implications that they have for our environment and its crisis. (shrink)

En plus de concevoir la vue et la pensée comme des processus empiriques capables de reproduire les caractéristiques des corps, Épicure reconnaît un processus psychophysique intermédiaire par le biais duquel les phantasiai ou représentations sont produites dans l’esprit et synthétisent les caractéristiques des objets sensibles. L’objectif de cet article est de monter qu’Épicure a retravaillé la doctrine de Démocrite dans cette direction, à la lumière de la critique aristotélicienne de certaines théories de la perception et de sa réflexion sur la (...) formation du phantasma. Nous étudions le processus physiologique à l’origine de la phantasia chez Épicure, et nous montrons son lien avec le processus psychophysique adopté par Aristote pour expliquer la représentation. (shrink)